FACTORS ASSOCIATED WITH NON-INVASIVE POSITIVE PRESSURE VENTILATION FAILURE IN A COVID-19 INTERMEDIATE CARE UNIT

TYPE: Abstract TOPIC: Critical Care PURPOSE: Evaluate the efficacy of NIPPV (CPAP, HELMET-CPAP or NIV) in COVID-19 patients treated Intermediate Unit Coimbra Hospital and Universitary Centre (CHUC), Portugal, assess factors associated with failure. METHODS: Patients admitted from December 1st 2020 to February 28th 2021, were included. Data collected on: demographic, radiological laboratory information, parameters medical treatment. The primary outcome was failure (orotracheal intubation (OTI) death during hospital stay). Factors an univariate significance level p<0.001 entered a multivariate logistic regression. RESULTS: 163 included, 64.4% males median age 66y. Overall, 97 (59.5%) successfully treated, while observed 66 (40.5%), which 26 (39.4%) intubated 40 (60.6%) died stay. Highest CRP stay (OR 1.164; 95%CI 1.036-1.308) morphine use 3.974; 0.539-29.302) identified as independent predictors Adherence prone 1.109; 0.017-0.700) higher value lowest platelet count 0.977; 0.960-0.994) favorable outcome. CONCLUSIONS: positioning CLINICAL IMPLICATIONS: is valid option treat acute respiratory should be help clinical decision making. DISCLOSURE: Nothing declare. KEYWORD: